| Autor: |
Hou Y; Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0212, USA., Cao S, Brodie P, Miller JS, Birkinshaw C, Ratovoson F, Rakotondrajaona R, Andriantsiferana R, Rasamison VE, Kingston DG |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 2008 Jan; Vol. 71 (1), pp. 150-2. Date of Electronic Publication: 2007 Dec 29. |
| DOI: |
10.1021/np070437l |
| Abstrakt: |
Bioassay-guided fractionation of an ethanol extract of a Madagascar collection of the fruits of Cordyla madagascariensis ssp. madagascariensis led to the isolation of the four new cassane diterpenoids 1-4. The 1H and 13C NMR spectra of all compounds were fully assigned using a combination of 2D NMR experiments, including COSY, HSQC, HMBC, and ROESY sequences. All of the isolates were tested against the A2780 human ovarian cancer cell line, and compounds 1 and 2 showed mild antiproliferative activity with IC50 values of 10 and 36 microM, respectively. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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