Antiproliferative, antioxidant, and antimutagenic activities of flavonoid-enriched extracts from (Tunisian) Rhamnus alaternus L.: combination with the phytochemical composition.

Autor: Ammar RB; Unité de Pharmacognosie/Biologie Moléculaire 99/UR/07-03, Faculté de Pharmacie, Monastir, Tunisie., Kilani S, Bouhlel I, Ezzi L, Skandrani I, Boubaker J, Sghaier MB, Naffeti A, Mahmoud A, Chekir-Ghedira L, Ghedira K
Jazyk: angličtina
Zdroj: Drug and chemical toxicology [Drug Chem Toxicol] 2008; Vol. 31 (1), pp. 61-80.
DOI: 10.1080/01480540701688725
Abstrakt: A pronounced antiproliferative effect on human leukemia K562 cells was shown with flavonoid-enriched extracts from Rhamnus alaternus roots and leaves, with, respectively, IC(50) values of 165 and 210.73 microg/mL. High DPPH radical-scavenging activity (7.21 and 18.84 microg/mL, respectively) and antioxidative effects using the xanthine oxidase assay (IC(50) values of 83.33 and 103.96 microg/mL, respectively) were detected in the presence of the two tested extracts. Although no mutagenic effect was observed when using the Salmonella typhimurium assay system with TA1535 and TA100 strains, the two tested extracts exhibited a high-level protection toward the direct mutagen, sodium azide-induced response.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje