[Effect of the methods of sterilization on the quality of nutrient media and on the level of antibiotic production].

Autor: Motina GL, Kalinina NM, Tarasova TM, Bryzgalova TE, Nekliudov AD, Mal'tsev NI, Lur'e LM
Jazyk: ruština
Zdroj: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] [Antibiot Khimioter] 1991 Dec; Vol. 36 (12), pp. 3-6.
Abstrakt: It was shown that conditions for heat sterilization of nutrient media for biosynthesis of antibiotics had an impact on their biochemical composition and activity of a fermentation broth in production of penicillin and erythromycin. The temperature of 120 degrees C and the time of 25 minutes proved to be optimal for sterilization of the media in regard to both preservation of their biochemical composition and providing of the maximum antibiotic productivity on the one hand and maintenance of the sterility during the fermentation process on the other hand.
Databáze: MEDLINE