| Autor: |
Balmelli C; Institute of Virology and Immunoprophylaxis, Sensemattstrasse 293, CH-3147, Mittelhäusern, Switzerland. Carole.Balmelli@ivi.admin.ch, Alves MP, Steiner E, Zingg D, Peduto N, Ruggli N, Gerber H, McCullough K, Summerfield A |
| Jazyk: |
angličtina |
| Zdroj: |
Immunobiology [Immunobiology] 2007; Vol. 212 (9-10), pp. 693-9. Date of Electronic Publication: 2007 Nov 13. |
| DOI: |
10.1016/j.imbio.2007.09.009 |
| Abstrakt: |
Circulating myeloid cells such as plasmacytoid dendritic cells (pDC), blood DC and monocytes act as blood sentinels detecting invading pathogens through a large repertoire of expression of toll-like receptors (TLRs). Activation of these receptors is crucial to detect invading pathogens by the innate immune system. In the present work, we analysed the TLR responsiveness of fibrocytes, a blood-derived cell type of myeloid origin. Fibrocytes efficiently responded to TLR2, TLR4, and TLR7 ligands as well as to poly (I:C) or viral stimulation by producing high amount of interleukin-6. Upon virus infection of fibrocytes, IFN type I was also induced. When compared to pDC or Flt3 ligand-derived DC, fibrocytes produced 5 times and 60 times more IL-6, respectively. This response was associated with a rapid and efficient translocation of the NF-kappaB transcription factor. Analysis of the expression and functionality of TLR7 in peripheral blood leukocyte subpopulations suggested that this receptor is expressed and functional in a CD163(+) monocytic cell subpopulation containing the fibrocyte precursors. Considering the rapid entry of fibrocytes into wounds, this efficient responsiveness to TLR danger signals, reflects a potentially important role of these cells in the first line of defence against pathogen invasion following traumata. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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