A convenient solid-phase method for the synthesis of novel oligonucleotide-folate conjugates.

Autor:	Kazanova EV; Department of Chemistry and A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonossov Moscow State University, Moscow, Russia., Zubin EM, Kachalova AV, Volkov EM, Oretskaya TS, Stetsenko DA, Gottikh MB
Jazyk:	angličtina
Zdroj:	Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2007; Vol. 26 (10-12), pp. 1273-6.
DOI:	10.1080/15257770701530459
Abstrakt:	We describe the preparation of two batches of a polymer support for the incorporation of folic acid into oligonucleotides. The method permits the regioselective attachment of a target nucleic acid sequence through its 3'-end to either the alpha-or gamma-carboxyl group of L-glutamic acid, respectively. The supports have been tested in solid-phase synthesis of oligonucleotide-folate conjugates for cell delivery studies.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.