| Autor: |
Burakova EA, Kovalev NA, Kuznetsova IL, Zenkova MA, Vlasov VV, Sil'nikov VN |
| Jazyk: |
ruština |
| Zdroj: |
Bioorganicheskaia khimiia [Bioorg Khim] 2007 Sep-Oct; Vol. 33 (5), pp. 563-70. |
| DOI: |
10.1134/s106816200705010x |
| Abstrakt: |
A number of tetracationic compounds capable of phosphodiester bond cleavage within a 21 -membered ribooligonucleotide were designed and synthesized. The artificial ribonucleases represent two residues of quaternized 1,4-diazabicyclo[2.2.2]octane bearing alkyl substituents of various lengths and connected with a rigid linker. The efficiency of cleavage of phosphodiester bonds in an RNA target depends on the linker structure and the length of alkyl substituent. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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