| Autor: |
Bell MG; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. bell_michael_g@Lilly.com, Gernert DL, Grese TA, Belvo MD, Borromeo PS, Kelley SA, Kennedy JH, Kolis SP, Lander PA, Richey R, Sharp VS, Stephenson GA, Williams JD, Yu H, Zimmerman KM, Steinberg MI, Jadhav PK |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 2007 Dec 27; Vol. 50 (26), pp. 6443-5. Date of Electronic Publication: 2007 Nov 27. |
| DOI: |
10.1021/jm701186z |
| Abstrakt: |
A novel, potent series of indole analogs were recently developed as MR antagonists, culminating in 14. This compound represents the first MR antagonist in this class of molecules, exhibiting picomolar binding affinity and in vivo blood pressure lowering at pharmaceutically relevant doses. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
