Morphological and biochemical characteristics in the experimentally treated rats with indigenous synthetical products used as pesticides.

Autor: Filipescu G; Victor Babeş Institute, Department of Pathology, Bucharest, Romania., Codorean E, Laky D, Tănase C, Ciotaru L
Jazyk: angličtina
Zdroj: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie [Rom J Morphol Embryol] 1991 Jan-Jun; Vol. 37 (1-2), pp. 49-54.
Abstrakt: In acute experimental intoxication with 3 indigenous pesticides (Tripinacloraz, Lemax and Maleic Hydrazide-Na salt) the changes of some biochemical parameters, reflecting the degree of hepatic structural alterations, were studied. The pesticides were administered by gastric gavage in a single dose close to DL50 to Wistar male rats. The morphological alterations were in good correlation with a different hepatocellular levels localization. Reversible morphological lesions (granulovascuolar like dystrophy and circulatory disorders) without any pathological significance on dose-effect correlation induced a progressive response especially on serum ceruloplasmine, leucinaminopeptidase and lactatdehydrogenase.
Databáze: MEDLINE