| Autor: |
Liu X; Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012, PR China. xinyongl@sdu.edu.cn, Yan R, Chen N, Xu W, Molina MT, Vega S |
| Jazyk: |
angličtina |
| Zdroj: |
Molecules (Basel, Switzerland) [Molecules] 2006 Nov 01; Vol. 11 (11), pp. 827-36. Date of Electronic Publication: 2006 Nov 01. |
| DOI: |
10.3390/11110827 |
| Abstrakt: |
The new compound 7-methylpyrazolo[4,5-e][1,2,4]thiadiazin-3(2H,4H)-one1,1-dioxide (5) was synthesized and its novel mono N2- or N4-substituted derivatives 6 and 7 were prepared by regioselective N-alkylation of 5 with different molar ratios of NaH and alkyl halides. Based on the regioselective alkylation conditions found a facile one-pot synthesis of N2,N4-disubstituted pyrazolo[4,5-e][1,2,4] thiadiazines 8 was developed. The structures of the newly synthesized compounds were confirmed by IR,(1)H-NMR, (13)C-NMR and MS spectral analysis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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