| Autor: |
Korstjens IJ; Department of Physiology, VU University Medical Center, Amsterdam, The Netherlands., van der Mooren MJ, Kloosterboer HJ, Sipkema P |
| Jazyk: |
angličtina |
| Zdroj: |
Menopause (New York, N.Y.) [Menopause] 2008 Mar-Apr; Vol. 15 (2), pp. 386-7. |
| DOI: |
10.1097/gme.0b013e3181407c6b |
| Abstrakt: |
In an earlier study, we focused on the vasoactive effect of 3alpha-OH-tibolone on spontaneously constricted isolatedfemale rat gracilis muscle arterioles. Vasodilator effects (from 10 to 10 M) of 3alpha-OH-tibolone were similar to those of 17beta-estradiol. It was reported that 3beta-OH-tibolone like estradiol altered GABAB activation in neurons through a membrane estrogen receptor, whereas the 3alpha-OH metabolite did not. We therefore hypothesized that the 3beta-OH metabolite may also have a vasodilating effect in our isolated arteriole model. The results indicate that 3beta-OH-tibolone induces a vasodilator effect in small arterioles that is comparable with that of 3alpha-OH-tibolone at the same concentration. This is intriguing because the binding affinity of 3alpha-OH-tibolone to the estrogen receptor is almost twice that of 3beta-OH-tibolone. Other mechanisms may play a role. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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