| Autor: |
Walker KZ; Centenary Institute of Cancer Medicine and Cell Biology, Sydney University, New South Wales, Australia., Boniface GR, Phippard AF, Harewood W, Bautovich GJ, Bundesen PG |
| Jazyk: |
angličtina |
| Zdroj: |
Thrombosis research [Thromb Res] 1991 Dec 15; Vol. 64 (6), pp. 691-701. |
| DOI: |
10.1016/0049-3848(91)90069-9 |
| Abstrakt: |
Injection of 99mTc-labeled Fab' fragments of the anti-fibrin antibody DD-3B6/22, in the baboon, resulted in clear visualisation of both fresh and aged autologous thrombi by gamma scintigraphy. Whole body scintigraphy, pharmacokinetics and urine analysis showed rapid renal excretion of the conjugate with little accumulation of label in other organs. 99mTc-DD-3B6/22 Fab' appears a suitable candidate for further investigation as a radioimaging agent for thrombi in humans. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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