Birth of a healthy boy after fertilization of cryopreserved oocytes with cryopreserved testicular spermatozoa from a man with nonmosaic Klinefelter syndrome.
| Autor: | Greco E; Center for Reproductive Medicine, European Hospital, Rome, Italy., Iacobelli M, Rienzi L, Fabris GF, Tesorio N, Tesarik J |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Fertility and sterility [Fertil Steril] 2008 Apr; Vol. 89 (4), pp. 991.e5-7. Date of Electronic Publication: 2007 Nov 05. |
| DOI: | 10.1016/j.fertnstert.2007.04.039 |
| Abstrakt: | Objective: To report the first birth with frozen spermatozoa and frozen oocytes in a case of nonmosaic Klinefelter syndrome. Design: Case report. Setting: Private IVF clinics and a university hospital. Patient(s): A 32-year-old woman and a 33-year-old man. Intervention(s): Testicular sperm extraction and cryopreservation, oocyte recovery and cryopreservation, intracytoplasmic sperm injection. Main Outcome Measure(s): Assessment of fertilization and chromosomal analysis of newborn child. Result(s): Three oocytes were injected and one embryo was obtained, resulting in the birth of a normal (46,XY) boy. Conclusion(s): Cryopreserved spermatozoa from a patient with nonmosaic Klinefelter syndrome can form normal embryos even with cryopreserved oocytes. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|