| Autor: |
Jilek S; Divisions of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon, 1011 Lausanne, Switzerland., Kuhle J, Meylan P, Reichhart MD, Pantaleo G, Du Pasquier RA |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of neuroimmunology [J Neuroimmunol] 2007 Dec; Vol. 192 (1-2), pp. 192-7. Date of Electronic Publication: 2007 Nov 05. |
| DOI: |
10.1016/j.jneuroim.2007.09.023 |
| Abstrakt: |
The mechanisms leading to CNS disorders after EBV infections are unclear. We report the case of a patient who developed a severe, but reversible, encephalopathy following an infectious mononucleosis. We detected no EBV DNA in the blood or in the cerebrospinal fluid (CSF) and no EBV-specific antibodies in the CSF. However, we found a potent MOG-specific cellular and humoral immune response. Interestingly, MOG-specific cellular immune response rapidly decreased, paralleling the improvement of clinical condition. In conclusion, this detailed study shows that acute EBV infection can trigger a potent auto-inflammatory response in the CNS, without evidence of an overt infection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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