| Autor: |
Salanueva IJ; Integrin Signaling Laboratory, Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain., Cerezo A, Guadamillas MC, del Pozo MA |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of cellular and molecular medicine [J Cell Mol Med] 2007 Sep-Oct; Vol. 11 (5), pp. 969-80. |
| DOI: |
10.1111/j.1582-4934.2007.00109.x |
| Abstrakt: |
Caveolae are unique organelles that are found in the plasma membrane of many cell types. They participate in various processes such as lipid recycling, cellular signalling and endocytosis. A variety of signalling molecules localize to caveolae in response to various stimuli, providing a potential mechanism for the spatial regulation of signal transduction pathways. Caveolin-1, a constitutive protein of caveolae, has been implicated in the regulation of cell growth, lipid trafficking, endocytosis and cell migration. Phosphorylation of caveolin-1 on Tyr 14 is involved in integrin-regulated caveolae trafficking and also in signalling at focal adhesions in migrating cells. In this review, we focus on recent studies that describe the role of caveolin-1 in integrin signal transduction, and how this interplay links extracellular matrix anchorage to cell proliferation, polarity and directional migration. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text