| Autor: |
Takakura K; Department of Oral Medicine, Oral and Maxillofacial Surgery, Tokyo Dental Collage, Ichikawa, Chiba, Japan., Takaki S, Takeda I, Hanaue N, Kizu Y, Tonogi M, Yamane GY |
| Jazyk: |
angličtina |
| Zdroj: |
The Bulletin of Tokyo Dental College [Bull Tokyo Dent Coll] 2007 May; Vol. 48 (2), pp. 47-56. |
| DOI: |
10.2209/tdcpublication.48.47 |
| Abstrakt: |
The aim of this study was to clarify the effects of the muscarinic receptor agonist, cevimeline, on saliva flow and expression of aquaporin5 (AQP5) in submandibular gland after X-ray irradiation. Using a previously established radiation-induced xerostomia model mouse, saliva flow from at 7 days before irradiation to at 28 days after irradiation was investigated in mice that were treated with cevimeline before or after irradiation. Radiation caused a significant decrease in saliva flow compared with nonirradiated salivary glands. Cevimeline post-treatment also caused a significant decrease in saliva flow. In contrast, cevimeline pre-treatment did not significantly decrease saliva flow. Expression of AQP5 fluorescent intensity and mRNA were also analyzed. Irradiation significantly decreased expression of AQP5 in submandibular gland. However, pre-treatment with cevimeline prevented this decrease in AQP5 expression. These data suggest that pretreatment with cevimeline prevents radiation-induced xerostomia and radiation-induced decrease in expression of AQP5 in submandibular gland. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
