| Autor: |
Coutant JE; Marion Merrell Dow Inc., Cincinnati, OH 45215-6300., Westmark PA, Nardella PA, Walter SM, Okerholm RA |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of chromatography [J Chromatogr] 1991 Sep 18; Vol. 570 (1), pp. 139-48. |
| DOI: |
10.1016/0378-4347(91)80208-t |
| Abstrakt: |
This work describes the methodology for the analysis of terfenadine and the acid metabolite of terfenadine in plasma using high-performance liquid chromatography. The use of solid-phase extraction allows the use of robotic or manual sample preparation for the efficient clean-up of terfenadine and terfenadine acid metabolite from plasma. Additional selectivity is obtained through the use of fluorescence detection. For terfenadine, the validated quantitation range of this method is 10.0-84.2 ng/ml with coefficients of variation of 5.7-30%. For terfenadine acid metabolite, the validated quantitation range of this method is 8.2-500 ng/ml with coefficients of variation of 4.1-24%. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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