| Autor: |
Choksi KB; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555-0643, USA., Roberts LJ 2nd, DeFord JH, Rabek JP, Papaconstantinou J |
| Jazyk: |
angličtina |
| Zdroj: |
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2007 Dec 28; Vol. 364 (4), pp. 761-4. Date of Electronic Publication: 2007 Oct 25. |
| DOI: |
10.1016/j.bbrc.2007.10.100 |
| Abstrakt: |
F2-isoprostanes (IsoPs), lipid peroxidation products, are markers that quantitatively measure levels of oxidative stress. IsoP levels increase in tissues and serum of aging animals suggesting an increase in oxidative stress. This supports the Free Radical Theory of Aging, which proposes that elevated levels of reactive oxygen species (ROS) cause macromolecular damage, and is a factor in the age-associated decline in tissue function. Numerous studies have shown that the longevity of long-lived mutant mice correlates with their resistance to oxidative stress. However, although the Ames dwarf (DW) mice show resistance to oxidative stress, it has not been shown that these mice have inherently lower levels of ROS. Our results show that the serum and liver IsoP levels in DW mice are lower at all ages suggesting that the lower levels of endogenous ROS production in DW mice may be a factor in their resistance to oxidative stress and longevity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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