Which patients become seizure free with antiepileptic drugs? An observational study in 821 patients with epilepsy.
| Autor: | Bauer J; Department of Epileptology, University of Bonn, Germany. juergen.bauer@ukb.uni-bonn.de, Buchmüller L, Reuber M, Burr W |
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| Jazyk: | angličtina |
| Zdroj: | Acta neurologica Scandinavica [Acta Neurol Scand] 2008 Jan; Vol. 117 (1), pp. 55-9. Date of Electronic Publication: 2007 Oct 24. |
| DOI: | 10.1111/j.1600-0404.2007.00940.x |
| Abstrakt: | Objectives: Analysis of factors influencing seizure outcome in antiepileptic drug treatment of epilepsy. Patients and Methods: Retrospective analysis of 500 patients with complete seizure control and 321 patients with refractory epilepsy (mean ages 33.3 and 32.1 years respectively). Results: The seizure-free group consisted of 377 patients with symptomatic/cryptogenic epilepsy (SCE; mean seizure control 45 months) and 123 patients with idiopathic generalized epilepsy (IGE; mean seizure control 61 months) (P = 0.02). Of the patients with SCE, 35.7% had achieved seizure control with monotherapy (MT), 29.6% with >or=2 AEDs. No single AED was superior in MT. Of the patients with IGE, 35.9% had become seizure free with MT, 15.6% on combination therapy (CT). Valproate MT was more commonly associated with seizure freedom than lamotrigine (P < 0.05). Conclusions: The results indicate that, in SCE, seizures can be controlled with carefully selected CT more commonly than suggested by previous studies. The seizure prognosis of patients with IGE presenting to a specialist in epilepsy may be worse than previously thought. |
| Databáze: | MEDLINE |
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