Relationship between arterial vascular calcifications seen on screening mammograms and biochemical markers of endothelial injury.

Autor: Pidal D; Unidad de Investigación del, Hospital de Jove, Gijón, Spain. dpidal@hotmail.com, Sánchez Vidal MT, Rodríguez JC, Corte MD, Pravia P, Guinea O, Pidal I, Bongera M, Escribano D, González LO, Díez MC, Venta R, Vizoso FJ
Jazyk: angličtina
Zdroj: European journal of radiology [Eur J Radiol] 2009 Jan; Vol. 69 (1), pp. 87-92. Date of Electronic Publication: 2007 Oct 22.
DOI: 10.1016/j.ejrad.2007.08.030
Abstrakt: To assess whether breast arterial calcifications (BAC) are associated with altered serum markers of cardiovascular risk, mammograms and records from 1759 women (age range: 45-65 years) screened for breast cancer were revised. One hundred and forty seven (8.36%) women showed BAC. A total of 136 women with BAC and controls (mean age: 57 and 55 years, respectively) accepted entering the study. There were no significant differences in serum levels of urea, glucose, uric acid, creatinine, total cholesterol, HDL-C, LDL-C, folic acid, vitamin B(12), TSH or cysteine, between both groups of patients. However, women with BAC showed higher serum levels of triglycerides (p=0.006), homocysteine (p=0.002) and hs-CRP (p=0.003) than women without BAC. Likewise, we found a significantly higher percentage of cases with an elevated LDL-C/HDL-C ratio (coronary risk index >2) amongst women with BAC than in women without BAC (56.7 and 38.2%, respectively; p=0.04). Our results indicate that the finding of BAC identify women showing altered serum markers of cardiovascular risk.
Databáze: MEDLINE