| Autor: |
Tsushima T; Dept. of Medical Oncology, KKR Sapporo Medical Center Tonan Hospital., Tsuji Y, Abe S, Tanaka S, Tamura F, Mizushima T, Makino K, Oura K, Honda K, Sumiyoshi T, Yoshizaki N, Kondo H |
| Jazyk: |
japonština |
| Zdroj: |
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2007 Oct; Vol. 34 (10), pp. 1647-50. |
| Abstrakt: |
Docetaxel and paclitaxel are demonstrated to be effective for use as salvage therapy for advanced gastric cancer. Both drugs are taxane derivatives but there is only partial cross-resistance between them. For breast cancer and ovarian cancer, there have been several reports that showed docetaxel is effective for paclitaxel-resistant cancer, and vice versa. We experienced two cases of advanced gastric cancer effectively treated by sequential therapy of docetaxel and paclitaxel. One patient was a 43-year-old woman with a type 4 gastric carcinoma, and the other a 51-year-old woman who had suffered a recurrence of the gastric cancer after a total gastrectomy. At first, chemotherapy failed, so we chose docetaxel/high-dose 5-FU (HDFU) for the second-line therapy. After resistance to Docetaxel/HDFU, paclitaxel was effective for third-line treatment of both patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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