[Study on the influence of biological characteristics to HIV/HCV co-infection among HIV infected illegal blood donors in China].

Autor:	Pan PL; National AIDS Reference Laboratory, National Center for AIDS STD Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China., Liu Z, Zhang YH, Long XS, Wu H, Jiang Y
Jazyk:	čínština
Zdroj:	Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi [Zhonghua Liu Xing Bing Xue Za Zhi] 2007 Jun; Vol. 28 (6), pp. 589-92.
Abstrakt:	Objective: To study the influence of biological characteristics on HCV/HIV co-infection, including HIV-1 sequence distance, HIV-1 viral load and CD4+ count. Methods: HIV-1 sequence distance was calculated by Clustal W and Phylip software while HIV-1 viral load being tested by NASBA and CD4+ count was tested using Epics XL of Coulter. Significance was determined by t-test using SPSS 12.0. Results: The mean HIV-1 genetic distances were 7.95% and 15.73% (P < 0.001) between those with HCV co-infection and those without. Their mean HIV-1 viral loads were 4.61 and 4.45 (P = 0.522) and their mean CD4I T counts were 308 and 251 (P = 0.161), respectively. Conclusion: Data showed that in the study group, the HIV/HCV co-infection had an influence on the HIV sequence distance, but did not have major impact on HIV-1 viral load and their mean CD4+ T count.
Databáze:	MEDLINE
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