| Autor: |
O'Byrne EM; CIBA-GEIGY Corporation, Research Department, Summit, NJ 07901., Roberts ED, Rubin AS, Blancuzzi V, Wilson D, Hall NR, Lehman TJ |
| Jazyk: |
angličtina |
| Zdroj: |
Agents and actions [Agents Actions] 1991 Sep; Vol. 34 (1-2), pp. 239-41. |
| DOI: |
10.1007/BF01993291 |
| Abstrakt: |
A histopathological scoring system which grades drug effects on cellular infiltration, pannus formation, cartilage degradation and bone resorption in L. casei-induced polyarthritis in rats is described. Reference anti-rheumatic and anti-inflammatory agents administered on days 2-60 after induction of arthritis were evaluated for effects on paw swelling weekly and graded histopathologic changes on day 60. This animal model affords a tool to evaluated therapeutic agents on the joint destruction resulting from chronic inflammation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
