| Autor: |
O'Byrne EM; CIBA-GEIGY Corporation, Research Department, Summit, NJ 07901., Paul PK, Blancuzzi V, Wilson D, Gunson D, Wang JZ, Mezrich RS, Douglas FL |
| Jazyk: |
angličtina |
| Zdroj: |
Agents and actions [Agents Actions] 1991 Sep; Vol. 34 (1-2), pp. 214-6. |
| DOI: |
10.1007/BF01993283 |
| Abstrakt: |
Intra-articular (i.a.) injection of papain causes a reversible loss of proteoglycan in intact rabbit knees. Twelve rabbits were scanned with magnetic resonance imaging (MRI) at 0, 24, 48 and 72 hours after 5 units of papain i.a. in a 1.5 Tesla Signa with a three inch surface coil using spin echo sequence. Total cartilage thickness in proton density images was 1.08 +/- 0.09 mm prior to papain injection. The magnetic resonance images showed a reduction in articular cartilage thickness in papain-treated rabbit femurs at 24 hours to 0.69 +/- 0.18 mm and partial restoration by 72 hours to 0.77 +/- 0.21 mm. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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