| Autor: |
Gunt HB; James L. Winkle College of Pharmacy, University of Cincinnati, OH 45267, USA., Kasting GB |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2007 Dec; Vol. 32 (4-5), pp. 254-60. Date of Electronic Publication: 2007 Aug 28. |
| DOI: |
10.1016/j.ejps.2007.07.009 |
| Abstrakt: |
The impact of hydration on the permeation of the antifungal drug, ketoconazole, through excised human nails in vitro was evaluated in diffusion cell studies. Nails treated with [(3)H]ketoconazole solvent-deposited onto the dorsal surface were maintained in incubators at 32 degrees C and exposed sequentially to relative humidities (dorsal side) of 15, 40, 80 and 100% over a period of 40 days. The ventral side was bathed in a pH 7.4 phosphate buffer. Ascending and descending humidity regimens were tested. Increasing the ambient RH from 15 to 100% enhanced permeation of radiolabel associated with [(3)H]ketoconazole by a factor of three. Diffusivities estimated from these data and the associated nail water contents (estimated in a separate study) can be described by a free volume theory. Therefore, formulations or treatments, which increase nail hydration, have potential to improve topical therapy for onychomycosis, if a favorable balance between drug delivery and growth conditions for the dermatophytes can be achieved. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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