| Autor: |
Akhmetov II, Popov DV, Mozhaĭskaia IA, Missina SS, Astratenkova IV, Vinogradova OL, Rogozkin VA |
| Jazyk: |
ruština |
| Zdroj: |
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova [Ross Fiziol Zh Im I M Sechenova] 2007 Aug; Vol. 93 (8), pp. 837-43. |
| Abstrakt: |
The aim of study was to investigate an allelic distribution of PPARA (G/C polymorphism), PPARG (Pro/Ala), PPARD (+294T/C) and PGCIA (Gly482Ser) genes in rowers (n=205) and controls (n=659), and to find correlation between genotypes and physiological parameters. Genotyping was performed by restriction fragment length polymorphism analysis. Physiological parameters were evaluated by PM 3 Rower Ergometer and MetaMax 3B Gas Analyzer. The frequencies ofPPARA G (90.1% vs. 83.6%) and PPARG Ala (23.1% vs. 16.2%) alleles in elite athletes, and of PPARD C (19.1% vs. 10.5%) and PGC1A Gly (75.4% vs. 66.5%) alleles in sub-elite athletes were significantly higher than in controls. Moreover, PPARA G (when oxygen pulse was measured) and PGC 1A Gly (when maximal aerobic power and anaerobic threshold (%) of VO2max were measured) alleles were associated with high values of aerobic performance. Thus, PPARA G, PPARG Ala, PPARD C and PGCIA Gly alleles can be considered as genetic markers associated with enhanced physical performance. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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