Can non-malignant biopsy features identify men at increased risk of biopsy-detectable prostate cancer at re-screening after 4 years?

Autor: Wolters T; Department of Urology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. t.wolters@erasmusmc.nl, Roobol MJ, Schröder FH, van der Kwast TH, Roemeling S, van der Cruijsen-Koeter IW, Bangma CH, van Leenders GJ
Jazyk: angličtina
Zdroj: BJU international [BJU Int] 2008 Feb; Vol. 101 (3), pp. 283-8. Date of Electronic Publication: 2007 Oct 08.
DOI: 10.1111/j.1464-410X.2007.07267.x
Abstrakt: Objectives: To identify pathological features in non-malignant sextant prostate needle biopsies and assess their predictive value for detecting prostate cancer on biopsy 4 years later.
Patients and Methods: We selected and reviewed the biopsy specimens of 121 men that were diagnosed as non-malignant during the first screening round of the European Randomized Study of Screening for Prostate Cancer (ERSPC), Rotterdam section. Of these 61 (50.4%) were positive for cancer during the second round (the result of a matched random sample). The biopsies were indicated by prostate-specific antigen levels of >or= 3.0 ng/mL. Specimens were scored for high-grade prostatic intraepithelial neoplasia (HGPIN), active and chronic inflammation, biopsy core length and glandular core length. The predictive value of the pathological features for detecting prostate cancer after 4 years was assessed.
Results: In the first-round biopsies the incidence of HGPIN was 7.1%; there was active inflammation in 22.4% and chronic inflammation in 51.0%. The mean core length was 9.3 mm and mean glandular core length 7.4 mm; the mean total biopsy length (sum of core lengths) was 56.3 mm and mean total glandular length (sum of glandular core lengths) was 44.6 mm. None of the pathological features in the initial round was significantly related to the detection of cancer in the second round.
Conclusions: In this study of non-malignant prostate biopsy specimens from a screened population, no pathological features could be identified that were predictive for detecting prostate cancer on biopsy 4 years later.
Databáze: MEDLINE
Externí odkaz: