| Autor: |
Galal SM; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt., Bedair MM, el-Sayed MA |
| Jazyk: |
angličtina |
| Zdroj: |
Journal de pharmacie de Belgique [J Pharm Belg] 1991 Sep-Oct; Vol. 46 (5), pp. 315-9. |
| Abstrakt: |
First (D1-) and second (D2-) derivative spectrophotometric methods for the determination of diloxanide furoate and metronidazole in two-component preparation are presented. The methods are based on the direct measurements of diloxanide furoate in 0.1N hydrochloric acid solution at 262 nm and 248 nm for D1- and D2- curves, respectively without the interference of the coexisting component. Metronidazole, on the other hand is determined before and after its acid extraction from chloroformic solution and the subsequent D1- measurement at 288 nm and D2- measurement at 296 nm. The methods have been applied for the determination of both components in laboratory made mixtures and in tablet with a coefficient of variation less than 2%. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
