| Autor: |
Milagre CD; Institute of Chemistry, State University of Campinas, 13084-971 Campinas, SP, Brazil., Milagre HM, Santos LS, Lopes ML, Moran PJ, Eberlin MN, Rodrigues JA |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of mass spectrometry : JMS [J Mass Spectrom] 2007 Oct; Vol. 42 (10), pp. 1287-93. |
| DOI: |
10.1002/jms.1173 |
| Abstrakt: |
Reactions promoting direct Mannich-type alpha-methylenation of alpha, beta and gamma-ketoesters have been monitored via electrospray ionization mass and tandem mass spectrometric experiments. Key intermediates of the catalytical cycle of this synthetically useful reaction have been intercepted and characterized. The mechanistic information provided by electrospray ionization mass spectrometry/mass spectrometry (ESI-MS/MS) guided the optimization of reaction conditions, allowing alpha-methyleneketoesters to be prepared in high yields (80-95%) and in high-enough purity for immediate further manipulation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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