Effects of quinones on free-radical processes of oxidation and fragmentation of hydroxyl-containing organic compounds.

Autor: Shadyro OI; Department of Chemistry of the Belarusian State University, Nezavisimosty av. 4, Minsk, Belarus. shadyro@open.by, Sosnovskaya AA, Edimecheva IP, Ostrovskaya NI, Kazem KM, Hryntsevich IB, Alekseev AV
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Nov 15; Vol. 17 (22), pp. 6383-6. Date of Electronic Publication: 2007 Sep 04.
DOI: 10.1016/j.bmcl.2007.08.076
Abstrakt: The coenzymes Q and Vitamin K(3), as well as their synthetic analogues, have been found to inhibit free-radical processes of fragmentation of hydroxyl-containing organic compounds and oxidation of the latter by molecular oxygen. It has been established that the observed effects are due to the ability of quinones to oxidize the alpha-hydroxyl-containing carbon-centered radicals formed from the starting compounds.
Databáze: MEDLINE