| Autor: |
Inman SJ; Department of Chemical Engineering and Chemical Technology, Imperial College London, South Kensington Campus, UK. sharon.inman@imperial.ac.uk, Briscoe BJ, Pitt KG, Shiu C |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of pharmaceutics [Int J Pharm] 2008 Feb 12; Vol. 349 (1-2), pp. 172-9. Date of Electronic Publication: 2007 Aug 19. |
| DOI: |
10.1016/j.ijpharm.2007.08.019 |
| Abstrakt: |
An adapted tensile stress methodology for the fracture of microcrystalline cellulose (MCC) tablets has been investigated and implemented. The application of the generally applied linear elastic fracture mechanic (LEFM) parameters used to describe the fracture behaviour of these porous systems has been discussed. The application of an effective crack length concept, comprising of the notch depth and a process zone length designated delta c, has enabled the localised non-linear response of the MCC tablets to be characterised in a quantified manner. The requirement of the composite value delta c is postulated to be a direct result of the internal properties of the tablet formed during the compaction process due to its strong dependence on porosity. The high compact relative density creates a greater possibility for both local small-scale plastic yielding at the crack tip, commonly found in polymer materials and microcracking ahead of the crack tip, typically observed in the fracture of ceramics. The extrapolated value of KIC0 of 0.72 MPa m0.5 found in this work lies within the range found in literature for this material indicating that the adopted procedure is acceptable for the determination of the resistance to fracture of MCC compacts. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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