| Abstrakt: |
One of the clinical features of chronic myeloid leukemia (CML) after splenectomy lies in the development of an unusual hyperthrombocytic syndrome. In the course of a long-term observation, 12 out of 14 patients subjected to splenectomy demonstrated maximum thrombocytosis ranging from 1.008 X 10(9) to 3.053 X 10(9)/l. Hemorrhagic manifestations occurred in 6 patients, no thromboses were recorded. Postsplenectomy hyperthrombocytosis is to a certain measure resistant to cytostatic therapy. Dissociation may occur--good readings of the leukogram with a high hyperthrombocytosis. According to the authors' and reported data, the postsplenectomy hyperthrombocytic syndrome in ALL patients is fraught with the danger of the occurrence of hemorrhagic manifestations and, to a less degree, of thromboses. |
