| Autor: |
Jurisson SS; Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ 08903., Hirth W, Linder KE, Di Rocco RJ, Narra RK, Nowotnik DP, Nunn AD |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology [Int J Rad Appl Instrum B] 1991; Vol. 18 (7), pp. 735-44. |
| DOI: |
10.1016/0883-2897(91)90012-a |
| Abstrakt: |
The neutral, seven coordinate complexes of technetium known as the BATO (Boronic acid Adducts of Technetium diOximes) complexes have shown their utility as myocardial and cerebral perfusion agents. The axial chloride ligand of the BATO complexes [99mTcCl(dioxime)3 BR] is labile to substitution by a competitive anion; under physiological conditions, the axial chloride ligand can be replaced by a hydroxy group. The chloro and hydroxy analogs have different biodistributions and single-pass cerebral extraction efficiencies. The influence of structure on the rate of the in vitro chloro/hydroxy exchange process has been studied. The mechanism of axial ligand exchange was found to be SN1-CB, which proceeds by way of a transient, neutral six coordinate complex. Evidence is presented which indicates that chloro/hydroxy exchange is not the mechanism by which BATO complexes are retained in the brain. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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