| Autor: |
Barreto AR; Department of Morphology, Faculty of Medicine, Federal University of Ceará, Rua Delmiro de Farias, sn, Fortaleza, CE CEP 60.416-030, Brazil., Cavalcante IC, Castro MV, Junqueira AF, Vale MR, Ribeiro RA, Souza MH, Brito GA |
| Jazyk: |
angličtina |
| Zdroj: |
Digestive diseases and sciences [Dig Dis Sci] 2008 Apr; Vol. 53 (4), pp. 990-6. Date of Electronic Publication: 2007 Sep 01. |
| DOI: |
10.1007/s10620-007-9957-3 |
| Abstrakt: |
Recent reports suggest increased incidence and severity of Clostridium difficile-associated diseases. These facts have raised the need for additional clarification of pathogenesis and for a search for new therapeutic strategies. This study evaluated the effects of the polysaccharide fucoidin, an L-selectin blocker, on toxin-A-induced mouse enteritis. Fucoidin (25 mg/kg) or saline (0.1 ml) were injected systemically (ocular plexus) 5 min prior to local challenge with toxin A (5 microg/ileal loop) or phosphate-buffered saline (PBS). Intestinal fluid volume/length and ileal loop weight/length ratios were calculated 3 h later. Ileal tissues were collected for histopathology and measurement of myeloperoxidase and adenosine deaminase activity. Fucoidin significantly (P < 0.05) prevented the toxin-A-induced increase in weight/length and volume/length ratios and reduced mucosal disruption, as shown in histopathology. Fucoidin also significantly (P < 0.05) reduced toxin-A-induced myeloperoxidase and adenosine deaminase activities. In conclusion, fucoidin reduces tissue injury and inflammation in toxin-A-induced mouse enteritis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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