[Long-term results of combined treatment of acute promyelocytic leukemia in children and adolescents with gene therapy].

Autor:	Samochatova EV, Maschan AA, Aleĭnikova OV, Bespalova AV, Baĭdil'dina DD, Dubrovina ME, Fleĭshman EV, Nasedkina TV, Rumiantsev SA, Rumiantsev AG
Jazyk:	ruština
Zdroj:	Terapevticheskii arkhiv [Ter Arkh] 2007; Vol. 79 (7), pp. 26-30.
Abstrakt:	Aim: To analyse the results of treatment of children and adolescents with acute promyelocytic leukemia (APL) including polychemotherapy and ATRA (protocols APL 93, 98 and 2003). Material and Methods: The course of the disease, modification of the treatment protocols with reduction of anthracyclines and ATRA doses, results of molecular monitoring of PML/RARalpha transcript have been analysed for 107 APL patients. Results: For prognosis of the disease important are initial characteristics of the patient and the time of the tumor regress assessed by molecular methods--establishment of molecular remission and molecular recurrence. Conclusions: In APL it is necessary to conduct molecular monitoring especially in patients at high risk and with poor prognosis in a decrease of treatment intensity for toxicity relief. Detection of molecular recurrence is indication for treatment. To raise efficacy of APL recurrence therapy it is necessary to design a special updated protocol.
Databáze:	MEDLINE
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