Retrospective study of factors affecting non-healing of wounds during hyperbaric oxygen therapy.
| Autor: | Oubre CM; Hyperbaric Studies, Hyperion Biotechnology, San Antonio, Texas, US, USA. cherie.oubre.ctr@brooks.af.mil, Roy A, Toner C, Kalns J |
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| Jazyk: | angličtina |
| Zdroj: | Journal of wound care [J Wound Care] 2007 Jun; Vol. 16 (6), pp. 245-50. |
| DOI: | 10.12968/jowc.2007.16.6.27066 |
| Abstrakt: | Objective: To identify potential factors, including cigarette smoking and diabetes status, that affect wound-healing outcomes during a six-week course of hyperbaric oxygen therapy (HBOT). Method: Seventy-three patients with 85 non-healing lower extremity wounds were treated with hyperbaric oxygen therapy (100% oxygen, 2.4 atmosphere absolute, (ATA), for 90 minutes). The wound area was evaluated over the six-week treatment period. Results: A non-hierarchical clustering analysis of normalised wound-area data revealed that healing responses could be segregated into three groups: robust healing (n=31, over 50% reduction in area), minimal healing (n=33, 15% reduction) and non-healing (n=21,60% increase in area). Further analysis revealed that cigarette smoking was associated with poor response (p<0.0001), whereas diabetes was not. Robust responders had higher blood levels of creatinine and urea nitrogen, increased peripheral oxygenation (TcpO2), and were younger than less responsive patients. Conclusion: The results suggest that response to HBOT is variable and some patients do not benefit from it. Clinicians should evaluate available laboratory values, age and social history to determine if a patient is likely to benefit from HBOT. |
| Databáze: | MEDLINE |
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