| Autor: |
do Amaral LL; Department of Neuroradiology, Medimagem, Hospital Beneficência Portuguesa, São Paulo, Brazil., Ferreira RM, Ferreira NP, Mendonça RA, Marussi VH, da Cunha JL, Maçaranduba BR, Medeiros JD |
| Jazyk: |
angličtina |
| Zdroj: |
AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2007 Aug; Vol. 28 (7), pp. 1369-70. |
| DOI: |
10.3174/ajnr.A0545 |
| Abstrakt: |
Mutations of the PROP-1 gene are the most frequent genetic defect in patients with combined pituitary hormone insufficiency. We present the cases of 2 siblings with PROP-1 mutations whom we observed longitudinally. Their initial pituitary MR imaging examinations showed identical findings: an enlarged adenohypophysis, with striking hypointensity on T2-weighted images and slight hyperintensity on T1-weighted images. In one of the children, the follow-up MR imaging obtained 3 years after hormonal replacement revealed a decrease in the size of the anterior pituitary lobe. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
