Cocaine disrupts pup-induced maternal behavior in juvenile and adult rats.

Autor: Johns JM; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7096, USA. jjohns@med.unc.edu, McMurray MS, Hofler VE, Jarrett TM, Middleton CL, Elliott DL, Mirza R, Haslup A, Elliott JC, Walker CH
Jazyk: angličtina
Zdroj: Neurotoxicology and teratology [Neurotoxicol Teratol] 2007 Nov-Dec; Vol. 29 (6), pp. 634-41. Date of Electronic Publication: 2007 Jul 14.
DOI: 10.1016/j.ntt.2007.07.003
Abstrakt: Impaired onset of maternal behavior in first generation rat dams was previously correlated with rearing by cocaine-treated dams and prenatal cocaine exposure. Pup-induced maternal behavior in non-lactating rats has not been examined with regard to cocaine exposure and rearing conditions. First generation male and female juveniles and young adult males reared by cocaine-treated or control dams and prenatally exposed to either cocaine or control conditions were tested for pup-induced maternal behavior at postnatal days 28 and 60. We now report disruptions in pup-induced maternal behavior in both 28 and 60 day old first generation offspring attributable to rearing condition and prenatal cocaine exposure.
Databáze: MEDLINE