| Autor: |
Javid N; University of Dortmund, Department of Chemistry, Physical Chemistry I-Biophysical Chemistry, Otto-Hahn Strasse 6, D-44227 Dortmund, Germany., Vogtt K, Krywka C, Tolan M, Winter R |
| Jazyk: |
angličtina |
| Zdroj: |
Physical review letters [Phys Rev Lett] 2007 Jul 13; Vol. 99 (2), pp. 028101. Date of Electronic Publication: 2007 Jul 13. |
| DOI: |
10.1103/PhysRevLett.99.028101 |
| Abstrakt: |
Experimentally derived static structure factors obtained for the aggregation-prone protein insulin were analyzed with a statistical mechanical model based on the Derjaguin-Landau-Verwey-Overbeek potential. The data reveal that the protein self-assembles into equilibrium clusters already at low concentrations. Furthermore, striking differences regarding interaction forces between aggregation-prone proteins such as insulin in the preaggregated regime and natively stable globular proteins are found. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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