| Autor: |
Sahu SK; University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar. Bhubaneswar-751 004, India. tutu_kh@yahoo.com, Banerjee M, Mishra SK, Mohanta RK, Panda PK, Misro PK |
| Jazyk: |
angličtina |
| Zdroj: |
Acta poloniae pharmaceutica [Acta Pol Pharm] 2007 Mar-Apr; Vol. 64 (2), pp. 121-6. |
| Abstrakt: |
Condensation of isatin with primary aryl amines gave a series of Schiff bases (1) which on reaction with thioglycolic acid in 1,4-dioxane afforded the formation of the corresponding 4- thiazolidinones (2). Compound 2 on condensation with substituted benzaldehydes in anhydrous sodium acetate furnished 3-aryl -5'-phenyl (substituted) spiro [3H-indole-3,2'-thiazolidines]-2-(1H), 4'(5'H)-diones (3). The latter (3) on reaction with hydrazine hydrochloride in anhydrous sodium acetate gave 3'-phenyl (substituted) -6'-aryl-2'(1H)-cis-3',3'a-dihydrospiro [3H-indole-3,5'-pyrazolo (3',4'-d)-thiazolo-2-(1H)-ones] (4). The structure has been established on the basis of spectral data. The partition coefficient for n-octanol/water solvent system and in vitro antibacterial activity of the 2'(1H)-cis-3',3'a-dihydrospiro [3H-indole-3,5'-pyrazolo (3',4'-d)-thiazolo-2-(1H)-one] derivatives have been evaluated. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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