[Association between HLA and leukemia in a mixed Brazilian population].
| Autor: | Barion LA; Departamento de Análises Clínicas, Universidade Estadual de Maringá, Av. Colombo 5790, Maringá, Paraná 87020-900, Brazil., Tsuneto LT, Testa GV, Lieber SR, Persoli LB, Marques SB, Vigorito AC, Aranha FJ, Eid KA, Oliveira GB, Miranda EC, Souza CA, Visentainer JE |
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| Jazyk: | portugalština |
| Zdroj: | Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2007 May-Jun; Vol. 53 (3), pp. 252-6. |
| DOI: | 10.1590/s0104-42302007000300024 |
| Abstrakt: | Objective: The main purpose of this study was to investigate the class I HLA antigens and class II HLA allele frequencies in 164 patients with leukemia: 35 patients with ALL (acute lymphoid leukemia), 50 with AML (acute myeloid leukemia) and 78 with CML (chronic myeloid leukemia). Methods: The genotyping of class I HLA was performed by microlymphocytotoxicity and of class II by PCR-SSP (polymerase chain reaction - sequence specific of primers) (One Lambda, Canoga Park, CA, USA). Results: In patients with LLA, frequencies of HLA-B45 and HLA-B56 were higher (P = 0.02; OR = 3.13; 95%IC = 0.94-10.44; P = 0.03; OR = 3.61; 95%IC = 0.47-27.64, respectively), than in controls. In patients with AML, the frequency of HLA-B7 (P = 0.01; OR = 2.41; 95%IC = 1.25-4.67) was higher than in controls. The presence of HLA-B45 (P= 0.01; OR = 3.29; 95%IC = 1.46-7.40), HLA-DRB1*04 (P = 0.002; OR = 2.17; 95%IC = 1.36-3.46) and HLA-DRB1*08 (P = 0.004; OR = 2.36; 95%IC = 1.34-4.16) was associated to increased risk of CML developing. Conclusion: Our results suggest that variants of HLA confer susceptibility to the same forms of leukemia, and could provide new tools for the investigation of genetics and etiology of this disease. |
| Databáze: | MEDLINE |
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