| Autor: |
Bae Y; Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705-2222, USA., Buresh RA, Williamson TP, Chen TH, Furgeson DY |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2007 Sep 11; Vol. 122 (1), pp. 16-23. Date of Electronic Publication: 2007 Jun 14. |
| DOI: |
10.1016/j.jconrel.2007.06.005 |
| Abstrakt: |
An intelligent biosynthetic nanobiomaterial (IBN) platform was explored for drug delivery applications for hyperthermic combination chemotherapy and thermal drug targeting. Geldanamycin (GA), a heat shock protein 90 inhibitor, was conjugated to novel thermosensitive poly(K)(8)-poly(VPGXG)(60) block copolymers [K(8)-ELP(1-60)] with guest residues as valine, alanine and glycine in a 5:2:3 ratio at the 'X' position. The conjugates were completely soluble in PBS and showed a characteristic thermosensitive inverse phase transition. [K(8)-ELP(1-60)]-GA conjugate nanoparticles showed a size ranging from 50 to 200 nm depending upon temperature. Relevant to systemic drug delivery in vivo, these IBNs stably disperse in aqueous solution. Cytotoxicity assays have shown that the IBN from [K(8)-ELP(1-60)]-GA conjugates exhibits effective hyperthermic combination chemotherapy with facile heat modulation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full Text from ScienceDirect