Characterization of antibody-binding sites on proteins: development of a knowledgebase and its applications in improving epitope prediction.

Autor: Ghate AD; Bioinformatics Centre, University of Pune, Pune 411007, India., Bhagwat BU, Bhosle SG, Gadepalli SM, Kulkarni-Kale UD
Jazyk: angličtina
Zdroj: Protein and peptide letters [Protein Pept Lett] 2007; Vol. 14 (6), pp. 531-5.
DOI: 10.2174/092986607780989921
Abstrakt: Immunoinformatics provides tools for reverse vaccinology and encompasses development of knowledge bases and algorithms for prediction of epitopes. AgAbDb, a database archiving molecular interactions of antigen-antibody co-crystal structures, has been developed (http://202.41.70.51:8080/agabdb2/). Analyses of antibody-binding sites on proteins helped to fine-tune the parameters for prediction of sequential and conformational B-cell epitopes.
Databáze: MEDLINE