| Autor: |
Weslow-Schmidt JL; Columbus Children's Research Institute, 700 Children's Drive, Columbus, OH 43205, USA., Jewell NA, Mertz SE, Simas JP, Durbin JE, Flaño E |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of virology [J Virol] 2007 Sep; Vol. 81 (18), pp. 9778-89. Date of Electronic Publication: 2007 Jul 11. |
| DOI: |
10.1128/JVI.00360-07 |
| Abstrakt: |
The respiratory tract is a major mucosal site for microorganism entry into the body, and type I interferon (IFN) and dendritic cells constitute a first line of defense against viral infections. We have analyzed the interaction between a model DNA virus, plasmacytoid dendritic cells, and type I IFN during lung infection of mice. Our data show that murine gammaherpesvirus 68 (gammaHV68) inhibits type I IFN secretion by dendritic cells and that plasmacytoid dendritic cells are necessary for conventional dendritic cell maturation in response to gammaHV68. Following gammaHV68 intranasal inoculation, the local and systemic IFN-alpha/beta response is below detectable levels, and plasmacytoid dendritic cells are activated and recruited into the lung with a tissue distribution that differs from that of conventional dendritic cells. Our results suggest that plasmacytoid dendritic cells and type I IFN have important but independent roles during the early response to a respiratory gammaHV68 infection. gammaHV68 infection inhibits type I IFN production by dendritic cells and is a poor inducer of IFN-alpha/beta in vivo, which may serve as an immune evasion strategy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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