Tick genomics: the Ixodes genome project and beyond.

Autor: Pagel Van Zee J; Purdue University, 901 West State Street, West Lafayette, IN 47907, USA., Geraci NS, Guerrero FD, Wikel SK, Stuart JJ, Nene VM, Hill CA
Jazyk: angličtina
Zdroj: International journal for parasitology [Int J Parasitol] 2007 Oct; Vol. 37 (12), pp. 1297-305. Date of Electronic Publication: 2007 Jun 09.
DOI: 10.1016/j.ijpara.2007.05.011
Abstrakt: Ticks and mites (subphylum Chelicerata; subclass Acari) include important pests of animals and plants worldwide. The Ixodes scapularis (black-legged tick) genome sequencing project marks the beginning of the genomics era for the field of acarology. This project is the first to sequence the genome of a blood-feeding tick vector of human disease and a member of the subphylum Chelicerata. Genome projects for other species of Acari are forthcoming and their genome sequences will likely feature significantly in the future of tick research. Parasitologists interested in advancing the field of tick genomics research will be faced with specific challenges. The development of genetic tools and resources, and the size and repetitive nature of tick genomes are important considerations. Innovative approaches may be required to sequence, assemble, annotate and analyse tick genomes. Overcoming these challenges will enable scientists to investigate the genes and genome organisation of this important group of arthropods and may ultimately lead to new solutions for control of ticks and tick-borne diseases.
Databáze: MEDLINE