| Autor: |
Ratner L; Division of Oncology, Washington University, St. Louis, Missouri 63110, USA. lratner@im.wustl.edu, Grant C, Zimmerman B, Fritz J, Weil G, Denes A, Suresh R, Campbell N, Jacobson S, Lairmore M |
| Jazyk: |
angličtina |
| Zdroj: |
American journal of hematology [Am J Hematol] 2007 Oct; Vol. 82 (10), pp. 929-31. |
| DOI: |
10.1002/ajh.20929 |
| Abstrakt: |
Human T-cell leukemia virus type 1 (HTLV-1) is associated with adult T-cell leukemia-lymphoma (ATLL) in about 5% of infected individuals. Coinfection by Strongyloides stercoralis has been suggested to be a cofactor for development of ATLL. We describe a patient who presented with HTLV-1-associated chronic ATLL and Strongyloides infection. Studies of this patient's viral RNA levels demonstrated stimulation of HTLV-1 replication by Strongyloides, which resolved with anti-helminthic therapy. This case provides support for the hypothesis that Strongyloides is a cofactor for ATLL via T-cell stimulation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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