| Autor: |
Kim JS; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA., Padnya A, Weltzin M, Edmonds BW, Schulte MK, Glennon RA |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Sep 01; Vol. 17 (17), pp. 4855-60. Date of Electronic Publication: 2007 Jun 14. |
| DOI: |
10.1016/j.bmcl.2007.06.047 |
| Abstrakt: |
Desformylflustrabromine (dFBr; 1) and desformylflustrabromine-B (dFBr-B; 2) have been previously isolated from natural sources, and the former has been demonstrated to be a novel and selective positive allosteric modulator of alpha4beta2 nicotinic acetylcholine (nACh) receptors. The present study describes the synthesis of water-soluble salts of 1 and 2, and confirms and further investigates the actions of 1 and 2 using two-electrode voltage clamp recordings. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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