| Autor: |
McGarrigle D; Department of Physiology, Cornell University Weill Medical College, New York, NY 10021, USA., Huang XY |
| Jazyk: |
angličtina |
| Zdroj: |
Science's STKE : signal transduction knowledge environment [Sci STKE] 2007 Jun 26; Vol. 2007 (392), pp. pe35. Date of Electronic Publication: 2007 Jun 26. |
| DOI: |
10.1126/stke.3922007pe35 |
| Abstrakt: |
A wide range of extracellular signals are transduced by G protein-coupled receptors (GPCRs). When activated by ligands, GPCRs can activate associated heterotrimeric guanine nucleotide-binding proteins (G proteins), which in turn act on various effectors. Increasing evidence indicates that GPCRs also signal independently of heterotrimeric G proteins. Several GPCRs directly interact with Src-family kinases. Here, we discuss the evidence for direct interaction and activation of Src-family kinases by GPCRs and data that suggest that agonist dosage provides a mechanism by which GPCRs can switch between G protein-dependent and G protein-independent signaling. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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