Methylenetetrahydrofolate reductase gene polymorphism is not related to the risk of ischemic cerebrovascular disease in a Brazilian population.
| Autor: | Marie SK; Department of Neurology, Central Institute of Clinical Hospital, School of Medicine, University of São Paulo, São Paulo, Brazil. sknmarie@usp.br, Shinjo SK, Oba-Shinjo SM, da Silva R, Barbosa KC, Yamamoto F, Scaff M |
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| Jazyk: | angličtina |
| Zdroj: | Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2007 Jun; Vol. 62 (3), pp. 295-300. |
| DOI: | 10.1590/s1807-59322007000300014 |
| Abstrakt: | Purpose: Data are conflicting concerning the risk for ischemic stroke associated with a common polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase C677T, which predisposes carriers to hyperhomocysteinemia. A meta-analysis study suggested that the 5,10-methylenetetrahydrofolate reductase 677TT genotype might have a small influence in determining susceptibility to ischemic stroke. Methods: We analyzed the 5,10-methylenetetrahydrofolate reductase 677TT genotype polymorphism in Brazilian subjects with ischemic stroke, using a case-control design. Results: We compared 5,10-methylenetetrahydrofolate reductase genotypes in groups of subjects presenting ischemic stroke (n = 127) and normal control (n = 126) and found an odds ratio of 1.97 (95% CI, 0.84-4.64) in a multivariate analysis in which results were adjusted to baseline clinical characteristics of study participants. Conclusion: We found that the homozygous 5,10-methylenetetrahydrofolate reductase C677T genotype was not a risk factor for ischemic stroke in these Brazilian subjects. |
| Databáze: | MEDLINE |
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