| Autor: |
Rekha PL; Immunogenetics Lab, Department of Genetics, Osmania University, Hyderabad, 500007, India. rekha_kirons@yahoo.co.in, Valluri V, Rakh SS, Pantula V, Ishaq M |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of clinical immunology [J Clin Immunol] 2007 Sep; Vol. 27 (5), pp. 486-9. Date of Electronic Publication: 2007 Jun 22. |
| DOI: |
10.1007/s10875-007-9102-2 |
| Abstrakt: |
The present study was designed to analyze the distribution of HLA DQ B1* and DR B1* in patients with goitrous juvenile autoimmune hypothyroidism from Hyderabad, India. Analysis indicated an increase in the frequencies of HLA DQ B1* 03 allele (P < 0.000) and HLA DR B1* 04 (P < 0.05) alleles in this group of patients when compared to the controls, whereas the frequency of DQB1* 05 was found to be decreased in patients' group compared to the controls (p < 0.01). To conclude, we report a positive correlation between DQ B1* 03 and DR B1* 04 and goitrous juvenile autoimmune hypothyroidism, whereas DQB1* 05 is observed to be negatively correlated with this thyroid dysfunction. Since the disease-susceptible HLA class II alleles appear to differ in various ethnic groups for some autoimmune diseases, the observed association from Indian series of patients holds significance. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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