| Autor: |
Ainge GD; Carbohydrate Chemistry Team, Industrial Research Limited, P.O. Box 31-310, Lower Hutt, New Zealand., Parlane NA, Denis M, Dyer BS, Härer A, Hayman CM, Larsen DS, Painter GF |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of organic chemistry [J Org Chem] 2007 Jul 06; Vol. 72 (14), pp. 5291-6. Date of Electronic Publication: 2007 Jun 09. |
| DOI: |
10.1021/jo070639m |
| Abstrakt: |
Phosphatidylinositol mannosides (PIMs) isolated from mycobacteria have been identified as an important class of glycolipids with significant immune modulating properties. We present here the syntheses of phosphatidylinositol dimannoside ether analogues 2 and 3 and evaluate their interleukin-12 (IL-12)-inducing properties along with dipalmitoyl PIM2 (1) in an in vitro bovine dendritic cell assay. Both synthetic PIM analogues and synthetic dipalmitoyl PIM2 (1) were effective at enhancing IL-12 production by immature bovine dendritic cells. Unexpectedly, ether analogue 2 was significantly more active than dipalmitoyl PIM2 (1) which indicates that modified PIM compounds can be strongly immunoactive and may have significant adjuvant activities. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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